In vitro effect of lead, silver, tin, mercury, indium and bismuth on human sperm creatine kinase activity: a presumable mechanism for men infertility.
Identifieur interne : 001360 ( Main/Exploration ); précédent : 001359; suivant : 001361In vitro effect of lead, silver, tin, mercury, indium and bismuth on human sperm creatine kinase activity: a presumable mechanism for men infertility.
Auteurs : RBID : pubmed:21725498English descriptors
- KwdEn :
- Bismuth (toxicity), Creatine Kinase (antagonists & inhibitors), Humans, Indium (toxicity), Infertility, Male (enzymology), Lead (toxicity), Male, Mercury (toxicity), Metals, Heavy (toxicity), Silver (toxicity), Spermatozoa (drug effects), Spermatozoa (enzymology), Spermatozoa (pathology), Tin (toxicity).
- MESH :
- chemical , antagonists & inhibitors : Creatine Kinase.
- chemical , toxicity : Bismuth, Indium, Lead, Mercury, Metals, Heavy, Silver, Tin.
- drug effects : Spermatozoa.
- enzymology : Infertility, Male, Spermatozoa.
- pathology : Spermatozoa.
- Humans, Male.
Abstract
The aim of the present study was to investigate the in vitro effects of mercury (Hg+2), lead (Pb+2), silver (Ag+2), tin (Sn+2), bismuth (Bi+3) and indium (In+3) ions on sperm creatine kinase.
PubMed: 21725498
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vitro effect of lead, silver, tin, mercury, indium and bismuth on human sperm creatine kinase activity: a presumable mechanism for men infertility.</title><author><name sortKey="Ghaffari, Mohammad Ali" uniqKey="Ghaffari M">Mohammad Ali Ghaffari</name><affiliation wicri:level="1"><nlm:affiliation>Cellular and Molecular Research Center and Physiology Research Center, Ahwaz Jundishapur University of Medical Sciences, Iran. ghaffarima@yahoo.com</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Cellular and Molecular Research Center and Physiology Research Center, Ahwaz Jundishapur University of Medical Sciences</wicri:regionArea></affiliation></author><author><name sortKey="Motlagh, Behrooz" uniqKey="Motlagh B">Behrooz Motlagh</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="RBID">pubmed:21725498</idno><idno type="pmid">21725498</idno><idno type="wicri:Area/Main/Corpus">001292</idno><idno type="wicri:Area/Main/Curation">001292</idno><idno type="wicri:Area/Main/Exploration">001360</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bismuth (toxicity)</term><term>Creatine Kinase (antagonists & inhibitors)</term><term>Humans</term><term>Indium (toxicity)</term><term>Infertility, Male (enzymology)</term><term>Lead (toxicity)</term><term>Male</term><term>Mercury (toxicity)</term><term>Metals, Heavy (toxicity)</term><term>Silver (toxicity)</term><term>Spermatozoa (drug effects)</term><term>Spermatozoa (enzymology)</term><term>Spermatozoa (pathology)</term><term>Tin (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Creatine Kinase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Bismuth</term><term>Indium</term><term>Lead</term><term>Mercury</term><term>Metals, Heavy</term><term>Silver</term><term>Tin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Spermatozoa</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Infertility, Male</term><term>Spermatozoa</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Spermatozoa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of the present study was to investigate the in vitro effects of mercury (Hg+2), lead (Pb+2), silver (Ag+2), tin (Sn+2), bismuth (Bi+3) and indium (In+3) ions on sperm creatine kinase.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21725498</PMID><DateCreated><Year>2011</Year><Month>07</Month><Day>04</Day></DateCreated><DateCompleted><Year>2012</Year><Month>02</Month><Day>06</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2008-823X</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><Issue>1-2</Issue><PubDate><Year>2011</Year></PubDate></JournalIssue><Title>Iranian biomedical journal</Title><ISOAbbreviation>Iran. Biomed. J.</ISOAbbreviation></Journal><ArticleTitle>In vitro effect of lead, silver, tin, mercury, indium and bismuth on human sperm creatine kinase activity: a presumable mechanism for men infertility.</ArticleTitle><Pagination><MedlinePgn>38-43</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The aim of the present study was to investigate the in vitro effects of mercury (Hg+2), lead (Pb+2), silver (Ag+2), tin (Sn+2), bismuth (Bi+3) and indium (In+3) ions on sperm creatine kinase.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">creatine kinase was isolated from human sperm homogenates after chromatography on a DEAE cellulose column.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At 60 mug ml-1 metal concentration, 70% of the creatine kinase activity was inhibited by Hg+2, while at the same concentration, Pb+2, Ag+2, Sn+2, Bi+3 and In+3 caused 68%, 66.5%, 65.7%, 64.7% and 62.7% inhibition, respectively. All six metal ions displayed a competitive type of inhibition mechanism for the isolated creatine kinase as analyzed by Lineweaver-Burk plot. Ki values of Hg+2, Pb+2, Ag+2, Sn+2, Bi+3 and In+3 were calculated and 8.34 mM, 5 mM, 4.54 mM, 3.45 mM, 3.12 mM and 2.63 mM values were obtained, respectively.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">All the studied metal ions, at levels of 60 mug ml-1, may reduce normal sperm metabolism by inhibition of sperm creatine kinase, which probably is an important cause of infertility in men. However, further investigations, as in vitro and in vivo, are needed to elucidate the exact mechanism of heavy metals on male reproductive functioning at the molecular level.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ghaffari</LastName><ForeName>Mohammad Ali</ForeName><Initials>MA</Initials><Affiliation>Cellular and Molecular Research Center and Physiology Research Center, Ahwaz Jundishapur University of Medical Sciences, Iran. ghaffarima@yahoo.com</Affiliation></Author><Author ValidYN="Y"><LastName>Motlagh</LastName><ForeName>Behrooz</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Iran</Country><MedlineTA>Iran Biomed J</MedlineTA><NlmUniqueID>9814853</NlmUniqueID><ISSNLinking>1028-852X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Metals, Heavy</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical><Chemical><RegistryNumber>2P299V784P</RegistryNumber><NameOfSubstance>Lead</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance>Silver</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-31-5</RegistryNumber><NameOfSubstance>Tin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.3.2</RegistryNumber><NameOfSubstance>Creatine Kinase</NameOfSubstance></Chemical><Chemical><RegistryNumber>FXS1BY2PGL</RegistryNumber><NameOfSubstance>Mercury</NameOfSubstance></Chemical><Chemical><RegistryNumber>U015TT5I8H</RegistryNumber><NameOfSubstance>Bismuth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>J Inorg Biochem. 2000 Apr;79(1-4):241-4</RefSource><PMID Version="1">10830873</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Environ Res. 2011 Jan;111(1):75-80</RefSource><PMID Version="1">20961536</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Physiol. 2001;63:289-325</RefSource><PMID Version="1">11181958</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Androl. 2001 Mar-Apr;46(2):127-34</RefSource><PMID Version="1">11297066</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Toxicology. 2003 Mar 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Version="1">17714845</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Fertil Steril. 2008 Feb;89(2 Suppl):e73-9</RefSource><PMID Version="1">18308070</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Reprod Toxicol. 2008 Apr;25(3):304-15</RefSource><PMID Version="1">18367374</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Med. 2009 Jul-Aug;15(7-8):248-62</RefSource><PMID Version="1">19593409</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Androl. 2000 Jun;23(3):145-9</RefSource><PMID Version="1">10844539</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Bismuth</DescriptorName><QualifierName MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Creatine Kinase</DescriptorName><QualifierName MajorTopicYN="N">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Infertility, Male</DescriptorName><QualifierName MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lead</DescriptorName><QualifierName MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mercury</DescriptorName><QualifierName MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Metals, Heavy</DescriptorName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Silver</DescriptorName><QualifierName MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Spermatozoa</DescriptorName><QualifierName MajorTopicYN="Y">drug effects</QualifierName><QualifierName MajorTopicYN="Y">enzymology</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tin</DescriptorName><QualifierName MajorTopicYN="N">toxicity</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3639739</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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